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5 These guidelines align with the American Diabetes Association (ADA) standards of care which also provide strong recommendations based on robust clinical trial data supporting the cardiovascular benefits of GLP-1 RAs, particularly in patients with established cardiovascular disease and chronic kidney disease (CKD)

Metabolic Signaling

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While nausea and vomiting are more common with short-acting agents, side effects such as itching or nodules at the injection site are more common with long-acting agents and usually disappear in 3 to 4 weeks